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新型四氢萘衍生物作为血栓素受体拮抗剂的合成及生物学评价

Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists.

作者信息

Cimetière B, Dubuffet T, Muller O, Descombes J J, Simonet S, Laubie M, Verbeuren T J, Lavielle G

机构信息

Institut de Recherches Servier, Centre de Recherches de Croissy, Croissy-sur-Seine, France.

出版信息

Bioorg Med Chem Lett. 1998 Jun 2;8(11):1375-80. doi: 10.1016/s0960-894x(98)00220-0.

DOI:10.1016/s0960-894x(98)00220-0
PMID:9871769
Abstract

New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886 has been identified as an orally active, highly potent antagonist with a very long duration of action in different species.

摘要

新型多取代四氢萘衍生物被制备作为血栓素受体（TP受体）拮抗剂。在这一系列化合物中，S 18886已被鉴定为一种口服活性高、效力强且在不同物种中作用持续时间极长的拮抗剂。

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