Claviez A, Neubauer B, Link J, Schneppenheim R
University of Kiel, Department of Pediatrics, Germany.
Klin Padiatr. 1998 Nov-Dec;210(6):406-8. doi: 10.1055/s-2008-1043912.
Since the majority of children with acute leukemia and lymphoma are long-term survivors, more attention is directed towards late sequelae of therapy. Intracerebral hemorrhage after treatment of central nervous system (CNS) neoplasia in childhood is a very rare event. A seven and a half-year-old boy was admitted to our hospital because of acute third nerve palsy. Three years and eight months before the patient had been treated for a mediastinal T-cell non Hodgkin's lymphoma (T-NHL) with CNS involvement by combined chemo-radiotherapy. Recurrent disease was excluded, but intracerebral hemorrhage in the tectal area was demonstrated by repeated magnetic resonance imaging. Symptoms of incomplete oculomotor paresis improved spontaneously with conservative therapy. Intracerebral hemorrhage may occur as a rare complication in children with malignant CNS disease even years after treatment with combined chemo-radiotherapy.
由于大多数急性白血病和淋巴瘤患儿都是长期幸存者，因此更多的注意力转向了治疗的晚期后遗症。儿童中枢神经系统（CNS）肿瘤治疗后发生脑出血是非常罕见的事件。一名7岁半的男孩因急性动眼神经麻痹入院。该患者在3年8个月前接受了联合放化疗，治疗的是伴有中枢神经系统受累的纵隔T细胞非霍奇金淋巴瘤（T-NHL）。排除了复发性疾病，但通过重复磁共振成像证实中脑顶盖区有脑出血。不完全动眼神经麻痹的症状通过保守治疗自发改善。即使在联合放化疗治疗数年之后，脑出血也可能作为恶性中枢神经系统疾病患儿的一种罕见并发症出现。
