在日本临床分离出的对磷霉素耐药的水生拉恩菌的外观。

Appearance of fosfomycin resistant Rahnella aquatilis clinically isolated in Japan.

作者信息

O'Hara K, Chen J, Shigenobu F, Nakamura A, Taniguchi K, Shimojima M, Ida H, Yoshikawa E, Tsuboi I, Mizuoka K, Sawai T

机构信息

Division of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan.

出版信息

Microbios. 1998;95(381):109-15.

PMID:9872000

Abstract

Among recent clinical isolates in Japan, strain CU264 was discovered which formed unusual colonies. This strain was identified as Rahnella aquatilis which is usually found in water. The antibiotic susceptibilities against tetracycline, carbenicillin, chloramphenicol, streptomycin, kanamycin, gentamicin, sulphonamide, neomycin, fosfomycin, rifampicin, norfloxacin and nalidixic acid, were investigated. The result demonstrated that the strain was highly resistant to fosfomycin only. It was further shown that this resistance was transmissible with low frequency to Serratia marcescens whereas it was not transmissible to Escherichia coli.

摘要

在日本近期的临床分离株中，发现了形成异常菌落的CU264菌株。该菌株被鉴定为水生拉恩菌，通常存在于水中。研究了该菌株对四环素、羧苄青霉素、氯霉素、链霉素、卡那霉素、庆大霉素、磺胺类、新霉素、磷霉素、利福平、诺氟沙星和萘啶酸的药敏性。结果表明，该菌株仅对磷霉素高度耐药。进一步研究表明，这种耐药性可低频率传递给粘质沙雷氏菌，但不能传递给大肠杆菌。