Polyakov A, Pratt H, Shi Y
Evoked Potentials Laboratory, Behavioral Biology, Technion-Israel Institute of Technology, Haifa.
Electroencephalogr Clin Neurophysiol. 1998 Nov;108(6):543-53. doi: 10.1016/s0168-5597(98)00034-3.
Auditory brain-stem evoked potentials (ABEPs) were recorded from 10 normal hearing subjects in response to rarefaction clicks, presented at a rate of 11/s. Stimuli were binaurally symmetrical and isochronic at 75 dB peSPL or with interaural time disparities (ITDs) of +/-0.4 ms, or intensity disparities (IIDs) of +/-10 dB. Potentials were recorded from vertex-neck, as well as from 3 orthonormally positioned differential derivations. The amplified potentials were averaged over 8000 repetitions using a dwell time of 20 micros/address/channel. The effects of contralateral stimulation on neural responses of the peripheral auditory system were obtained by subtracting the binaural response from the algebraic sum of responses to left and right monaural stimuli. From the 3 orthonormal derivations, 3-channel Lissajous' trajectories (3-CLTs) to the various stimulus conditions and difference waveforms were derived.
The results corroborated earlier studies on binaural interaction components (BICs), which include 3 major components corresponding in latency to the vertex-mastoid peaks IV-VI of ABEP. In addition, the binaural difference waveforms included 3 earlier, low-amplitude components. Latency correspondence and comparison of difference waveform and ABEP 3-CLTs indicated that the first and third early difference waveform components corresponded to the negative peaks following I and III, respectively, of the vertex-neck ABEP to binaural clicks.
These results indicate that early ABEP peaks, generated peripheral to binaural convergence, may be affected by contralateral stimulation. These contralateral effects were in a pattern compatible with suppression. most probably by efferents of the olivo-cochlear bundle.
对10名听力正常的受试者记录听觉脑干诱发电位（ABEP），以11次/秒的速率给予疏波短声刺激。刺激为双耳对称且等时的，声压级为75 dB peSPL，或双耳时间差（ITD）为±0.4 ms，或强度差（IID）为±10 dB。从头顶 - 颈部记录电位，同时也从3个相互垂直的差分导联记录。放大后的电位在8000次重复刺激下进行平均，每个地址/通道的驻留时间为20微秒。通过从左右单耳刺激反应的代数和中减去双耳反应，获得对侧刺激对外周听觉系统神经反应的影响。从3个相互垂直的导联中，得出针对各种刺激条件和差异波形的三通道利萨如图形轨迹（3 - CLT）。
结果证实了早期关于双耳相互作用成分（BIC）的研究，其中包括3个主要成分，其潜伏期与ABEP的头顶 - 乳突峰IV - VI相对应。此外，双耳差异波形包括3个更早出现的低幅成分。差异波形与ABEP 三通道利萨如图形轨迹的潜伏期对应和比较表明，差异波形的第一和第三个早期成分分别对应于双耳短声刺激时头顶 - 颈部ABEP的I和III之后的负峰。
这些结果表明，在双耳汇聚外周产生的早期ABEP峰可能受到对侧刺激的影响。这些对侧效应呈现出与抑制相符的模式，很可能是由橄榄耳蜗束的传出神经引起的。
