Guarrera M, Cipriani C, Rebora A
Department of Dermatology, University of Genoa, Italy.
Dermatology. 1998;197(4):335-7. doi: 10.1159/000018027.
In case the shedding telogen hair is not replaced in time by a terminal anagen hair, an empty space results.
To verify whether the phenomenon is present in prepubertal subjects.
From July 1996 to May 1997, an 8-year-old boy was submitted monthly to the phototrichogram technique. Sixty hairs were monitored throughout the study.
52% of all studied hairs were terminal anagen hairs throughout the study and additionally 22% were in a regular hair cycle. Vellus hairs and empty spaces were observed in 18 and 8% of follicles, respectively. In 2% of hairs, vellus hairs and empty spaces were associated.
Vellus hairs and empty spaces are present even in children. Without gonadal androgens and expression or induction of 5alpha-reductase in the prepubertal scalp, they are unlikely to herald androgenetic alopecia (AGA) but could reflect a physiological phenomenon of 'true resting' of a small proportion of scalp hair. Androgens may increase the phenomenon which may account in part for AGA development.
如果脱落的休止期毛发没有及时被生长期终毛替代，就会形成一个空位。
验证该现象是否存在于青春期前的受试者中。
从1996年7月至1997年5月，一名8岁男孩每月接受毛发照像技术检查。在整个研究过程中监测60根毛发。
在整个研究过程中，所有研究毛发中有52%为生长期终毛，另外22%处于正常毛发周期。毳毛和空位分别在18%和8%的毛囊中观察到。在2% 的毛发中，毳毛和空位同时存在。
即使在儿童中也存在毳毛和空位。在青春期前头皮中没有性腺雄激素以及5α-还原酶的表达或诱导，它们不太可能预示雄激素性脱发（AGA），但可能反映了一小部分头皮毛发“真正休止”的生理现象。雄激素可能会增加这种现象，这可能部分解释了AGA的发生。
