卟啉化合物对电鳗乙酰胆碱酯酶的抑制作用。
Inhibition of electric eel acetylcholinesterase by porphin compounds.
作者信息
Lee B H, Park M B, Yu B S
机构信息
Department of Industrial Chemistry, Taejon National University of Technology, Korea.
出版信息
Bioorg Med Chem Lett. 1998 Jun 16;8(12):1467-70. doi: 10.1016/s0960-894x(98)00236-4.
PMID:9873371
Abstract
Synthetic porphin compounds have been found to be reversible inhibitors of acetylcholinesterase from electric eel with Ki values of microM range. It seems that the number and position of fluorine on the phenyl ring and metal of an inhibitor play an important role for binding of an inhibitor to the enzyme active site.
摘要
已发现合成卟啉化合物是来自电鳗的乙酰胆碱酯酶的可逆抑制剂，其抑制常数（Ki）值在微摩尔范围内。抑制剂苯环上氟原子的数量和位置以及金属似乎对抑制剂与酶活性位点的结合起着重要作用。
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