Yamada M, Okagaki C, Higashijima T, Tanaka S, Ohnuki T, Sugita T
Lead Generation Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Bioorg Med Chem Lett. 1998 Jun 16;8(12):1537-40. doi: 10.1016/s0960-894x(98)00259-5.
A series of novel potent inhibitors of dipeptidyl peptidase IV (DPP-IV) has been developed. A brief structure-activity relationship of the inhibitors was investigated. The dipeptide TSL-225, tryptophyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, was identified with the critical structure for the inhibitory activity.
已经开发出一系列新型的强效二肽基肽酶IV（DPP-IV）抑制剂。对这些抑制剂的构效关系进行了简要研究。二肽TSL-225，即色氨酰-1,2,3,4-四氢异喹啉-3-羧酸，被确定为具有抑制活性的关键结构。
