A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P3 and its effect on Cl(-)-secretion from T84 cells.
作者信息
Rudolf M T, Traynor-Kaplan A E, Schultz C
机构信息
Abt. Bioorganische Chemie, Universität Bremen, Germany.
出版信息
Bioorg Med Chem Lett. 1998 Jul 21;8(14):1857-60. doi: 10.1016/s0960-894x(98)00322-9.
PMID:9873447
Abstract
The synthesis of rac-2,5,6-tri-O-butyryl-myo-inositol 1,3,4-trisphosphate hexakis(acetoxymethyl) ester [Bt3-Ins(1,3,4)P3/AM, 1], a membrane-permeant derivative of myo-inositol 1,3,4-trisphosphate [Ins(1,3,4)P3] is reported. 1 inhibited calcium-mediated chloride secretion of T84 cells, suggesting a regulatory link of Ins(1,3,4)P3 and the biosynthesis of the known inhibitor myo-inositol 3,4,5,6-tetrakisphosphate.
摘要
Zotero 插件