Stark H, Ligneau X, Arrang J M, Schwartz J C, Schunack W
Institut für Pharmazie I, Freie Universität Berlin, Germany.
Bioorg Med Chem Lett. 1998 Aug 4;8(15):2011-6. doi: 10.1016/s0960-894x(98)00342-4.
Novel omega-phenyl substituted and unsubstituted alkyl and alkenyl imidazole derivatives were prepared and tested for their antagonist activity in vitro and in vivo at histamine H3-receptors. Some compounds showed high in vitro and in vivo H3-receptor activity despite their structure bearing no polar moiety in the centre of the molecule which is a common structural feature of all other antagonists known. Quite probably there are further in vivo effects for some compounds resulting from other receptor interactions.
