Massa M A, Patt W C, Ahn K, Sisneros A M, Herman S B, Doherty A
Medicinal Chemistry Department, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105, USA.
Bioorg Med Chem Lett. 1998 Aug 18;8(16):2117-22. doi: 10.1016/s0960-894x(98)00375-8.
A series of bi-aryl pyridine carboxylic acids has been prepared and evaluated as inhibitors of ECE-1. The analogs were prepared by Pd catalyzed cross couplings of halogenated pyridines with heteroaryl organo-boranes, -tinate or -zincate derivatives.
已经制备了一系列联芳基吡啶羧酸，并作为ECE-1抑制剂进行了评估。这些类似物是通过钯催化卤代吡啶与杂芳基有机硼烷、有机锡酸盐或有机锌酸盐衍生物的交叉偶联反应制备的。
