一种HIV-1逆转录酶抑制剂奈韦拉平的二吡啶并[2,3-b:3',2'-f]氮杂卓类似物。
A dipyrido [2,3-b:3',2'-f]azepine analog of the HIV-1 reverse transcriptase inhibitor nevirapine.
作者信息
Dyatkin A B, Brickwood J R, Proudfoot J R
机构信息
Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.
出版信息
Bioorg Med Chem Lett. 1998 Aug 18;8(16):2169-72. doi: 10.1016/s0960-894x(98)00369-2.
PMID:9873507
Abstract
The syntheses of 11-ethyl and 11-cyclopropyldipyrido[2,3-b:3',2'-f]azepines, analogs of the HIV-1 reverse transcriptase inhibitor nevirapine 1, are described. These compounds exhibit potency equivalent to nevirapine in the inhibition of wild-type and some mutant RT enzymes.
摘要
描述了11-乙基和11-环丙基二吡啶并[2,3-b:3',2'-f]氮杂䓬的合成，它们是HIV-1逆转录酶抑制剂奈韦拉平1的类似物。这些化合物在抑制野生型和某些突变型RT酶方面表现出与奈韦拉平相当的效力。
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