Liddle J, Huffman J W, Wiley J L, Martin B R
Department of Chemistry, Clemson University, SC 29634-1905, USA.
Bioorg Med Chem Lett. 1998 Aug 18;8(16):2223-6. doi: 10.1016/s0960-894x(98)00385-0.
An enantioselective synthesis of the (1'S,2'R)-dimethylheptyl cannabinoid side chain has been developed and employed in the synthesis of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC (3). Pharmacology, in vivo and in vitro, indicate (3) to be one of the most potent traditional cannabinoids known.
