Ida Y, Satoh Y, Katsumata M, Nagasao M, Hirai Y, Kajimoto T, Katada N, Yasuda M, Yamamoto T
School of Pharamaceutical Sciences, Showa University, Tokyo, Japan.
Bioorg Med Chem Lett. 1998 Sep 22;8(18):2555-8. doi: 10.1016/s0960-894x(98)00457-0.
Two novel triterpene glycosides, achyranthosides E and F, were isolated as methyl esters from the root of Achyranthes fauriei, an antiinflammatory medicinal plant. Their structures were characterized as oleanolic acid glucuronides having unique substituents composed of C6H9O5 and C9H15O7, respectively, at the C-3 position of glucuronic acid. These compounds are active components which can inhibit the excess recruiting of neutrophiles to injured tissues 1,000 times more potently than sialyl Lewis X.
从抗炎药用植物牛鞭草的根部分离得到两种新型三萜糖苷，牛膝皂苷E和F，均为甲酯形式。它们的结构被鉴定为齐墩果酸葡萄糖醛酸苷，在葡萄糖醛酸的C-3位分别具有由C6H9O5和C9H15O7组成的独特取代基。这些化合物是活性成分，能够抑制嗜中性粒细胞向损伤组织的过度募集，其效力比唾液酸化路易斯X强1000倍。
