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The synthesis and biological activity of a novel series of diazepine MMP inhibitors.

作者信息

Levin J I, DiJoseph J F, Killar L M, Sung A, Walter T, Sharr M A, Roth C E, Skotnicki J S, Albright J D

机构信息

Wyeth-Ayerst Research, Pearl River, NY 10965, USA.

出版信息

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2657-62. doi: 10.1016/s0960-894x(98)00473-9.

DOI:10.1016/s0960-894x(98)00473-9
PMID:9873598
Abstract

A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vivo.

摘要

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