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Thalidomide analogs and PDE4 inhibition.

作者信息

Muller G W, Shire M G, Wong L M, Corral L G, Patterson R T, Chen Y, Stirling D I

机构信息

Celgene Corporation, Warren, NJ 07059 USA.

出版信息

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2669-74. doi: 10.1016/s0960-894x(98)00475-2.

DOI:10.1016/s0960-894x(98)00475-2
PMID:9873600
Abstract

N-Phthaloyl 3-amino-3-arylpropionic acid analogs of thalidomide that are potent inhibitors of tumor necrosis factor-alpha are reported. These compounds were found to be potent inhibitors of phosphodiesterase 4.

摘要

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