某些γ-芳氧基甲基-α-亚甲基-γ-苯基-γ-丁内酯的合成与抗癌活性评价
Synthesis and anticancer evaluation of certain gamma-aryloxymethyl-alpha-methylene-gamma-phenyl-gamma-butyrolactones.
作者信息
Wang T C, Lee K H, Chen Y L, Liou S S, Tzeng C C
机构信息
School of Chemistry, Kaohsiung Medical College, Taiwan, R.O.C.
出版信息
Bioorg Med Chem Lett. 1998 Oct 6;8(19):2773-6. doi: 10.1016/s0960-894x(98)00487-9.
Certain gamma-aryloxymethyl-alpha-methylene-gamma-phenyl- gamma-butyrolactones were synthesized and evaluated for their anticancer activity. These compounds demonstrated a strong growth inhibitory activity against leukemia cell lines but are relatively inactive against non-small cell lung cancers and CNS cancers. The anticancer potency for aryl portion is in an order of quinoline > 8-hydroxyquinoline > 2-methylquinoline >> naphthalene >> benzene.
合成了某些γ-芳氧基甲基-α-亚甲基-γ-苯基-γ-丁内酯，并对其抗癌活性进行了评估。这些化合物对白血病细胞系表现出很强的生长抑制活性，但对非小细胞肺癌和中枢神经系统癌症相对无活性。芳基部分的抗癌效力顺序为喹啉>8-羟基喹啉>2-甲基喹啉>>萘>>苯。
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