探索β-转角支架基序作为唾液酸化路易斯（X）模拟物的组成部分及其与P-选择素的相关性。
Exploration of beta-turn scaffolding motifs as components of sialyl Le(X) mimetics and their relevance to P-selectin.
作者信息
Hanessian S, Huynh H K, Reddy G V, McNaughton-Smith G, Ernst B, Kolb H C, Magnani J, Sweeley C
机构信息
Department of Chemistry, Université de Montréal, Centre-ville, Montréal, Québec, Canada.
出版信息
Bioorg Med Chem Lett. 1998 Oct 6;8(19):2803-8. doi: 10.1016/s0960-894x(98)00500-9.
PMID:9873626
Abstract
Monocyclic and bicyclic lactam units representing beta-turn surrogates were incorporated into a sialyl Le(X) structure by replacement of the natural sugar components. Low micromolar activity was found in a new P-selectin binding assay.
摘要
通过取代天然糖成分，将代表β-转角替代物的单环和双环内酰胺单元引入唾液酸化路易斯X（sialyl Le(X)）结构中。在一项新的P-选择素结合试验中发现了低微摩尔活性。
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