Rational design of a new series of mixed anti-HIV pronucleotides.
作者信息
Schlienger N, Beltran T, Périgaud C, Lefebvre I, Pompon A, Aubertin A M, Gosselin G, Imbach J L
机构信息
Laboratoire de Chimie Bioorganique, U.M.R. C.N.R.S. 5625, Université Montpellier II, France.
出版信息
Bioorg Med Chem Lett. 1998 Nov 3;8(21):3003-6. doi: 10.1016/S0960-894X(98)00535-6.
PMID:9873664
Abstract
MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide series.
摘要
Zotero 插件