通过前N10-三氯乙氧羰基保护和铃木耦合反应合成新型C7-芳基取代的吡咯并[2,1-c][1,4]苯并二氮杂卓（PBDs）
Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling.
作者信息
Guiotto A, Howard P W, Baraldi P G, Thurston D E
机构信息
CRC Gene Targeted Drug Design Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hants, U.K.
出版信息
Bioorg Med Chem Lett. 1998 Nov 3;8(21):3017-8. doi: 10.1016/S0960-894X(97)10083-X.
PMID:9873667
Abstract
Novel C7-aryl pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized via Suzuki coupling between a 7-Iodo N10-Troc-protected PBD carbinolamine and commercially available boronic acids.
摘要
新型C7-芳基吡咯并[2,1-c][1,4]苯并二氮杂卓（PBDs）已通过7-碘代N10-三苯甲基保护的PBD甲醇胺与市售硼酸之间的铃木偶联反应合成。
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