一系列γ-氨基丁酸（GABA）亚磺酸类似物的合成及其对GABAB受体亲和力的评估。
Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABAB receptor affinities.
作者信息
Carruthers N I, Spitler J M, Wong S C, Blythin D J, Chen X, Shue H J, She H S, Lee J F, Rizzo C, Ting P C, West R E
机构信息
Department of Chemical Research, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
出版信息
Bioorg Med Chem Lett. 1998 Nov 3;8(21):3059-64. doi: 10.1016/S0960-894X(98)00565-4.
PMID:9873676
Abstract
A series of gamma-aminobutyric acid (GABA) 1 analogs was prepared in which the carboxylic acid group of GABA was replaced with a sulfinic acid group and their affinity for the GABAB receptor investigated.
摘要
制备了一系列γ-氨基丁酸（GABA）1类似物，其中GABA的羧酸基团被亚磺酸基团取代，并研究了它们对GABAB受体的亲和力。
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