New phthalimide derivatives with potent analgesic activity: II.
作者信息
Antunes R, Batista H, Srivastava R M, Thomas G, Araujo C C
机构信息
Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, Brazil.
出版信息
Bioorg Med Chem Lett. 1998 Nov 3;8(21):3071-6. doi: 10.1016/S0960-894X(98)00558-7.
PMID:9873678
Abstract
Seven new phthalimide derivatives (9a-g) with 1,2,4-oxadiazol-5-yl methyl group attached to nitrogen have been synthesized from N-phthaloylglycine 6 and arylamidoximes 7a-g. All of these showed potent analgesic effect with acetic acid induced "writhing" test in mice. One of the better compounds (ID50 = 2.2 mg/Kg i.p.) has been found to be 9a which also demonstrates analgesic activity against inflammatory pain.
摘要
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