10-ω-苯基烷基-9(10H)-蒽酮作为角质形成细胞生长的抑制剂，具有降低的膜损伤特性。
10-omega-phenylalkyl-9(10H)-anthracenones as inhibitors of keratinocyte growth with reduced membrane damaging properties.
作者信息
Müller K, Breu K
机构信息
Institut für Pharmazeutische Chemie, Westfälische Wilhelms-Universität Münster, Germany.
出版信息
Bioorg Med Chem Lett. 1998 Nov 17;8(22):3211-6. doi: 10.1016/s0960-894x(98)00580-0.
PMID:9873705
Abstract
Work aimed at further improving the benefit to risk ratio of the antipsoriatic agent anthralin has led to 10-omega-phenylalkyl-9(10H)-anthracenones, members of which are equally potent as inhibitors of the growth of HaCaT keratinocytes. In contrast to anthralin, induction of membrane injury is strongly reduced as documented by the release of LDH activity from cytoplasm of keratinocytes.
摘要
旨在进一步提高抗银屑病药物蒽林的效益风险比的研究工作已产生了10-ω-苯基烷基-9(10H)-蒽酮，其中的成员作为HaCaT角质形成细胞生长抑制剂的效力相当。与蒽林不同，如角质形成细胞胞质中乳酸脱氢酶活性的释放所证明的，膜损伤的诱导作用大幅降低。
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