具有DNA嵌入剂和糖部分的九元环掩蔽烯二炔类似物的DNA切割活性。
DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties.
作者信息
Takahashi T, Tanaka H, Matsuda A, Doi T, Yamada H, Matsumoto T, Sasaki D, Sugiura Y
机构信息
Department of Chemical Engineering, Tokyo Institute of Technology, Japan.
出版信息
Bioorg Med Chem Lett. 1998 Dec 1;8(23):3303-6. doi: 10.1016/s0960-894x(98)00606-4.
PMID:9873723
Abstract
The DNA cleaving properties of various enediyne analogues possessing sugar moieties and DNA-intercalators were investigated. The DNA cleaving experiments show that these hybrids analogues induced sequence-selective DNA cleavage and the simple sugars in the enediyne serve as a DNA recognition element for DNA cleavage.
摘要
对各种带有糖基部分和DNA嵌入剂的烯二炔类似物的DNA切割特性进行了研究。DNA切割实验表明，这些杂合类似物可诱导序列选择性DNA切割，且烯二炔中的单糖作为DNA切割的DNA识别元件。
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