新型C3-氮杂碳环流感病毒神经氨酸酶抑制剂系列：合成与抑制活性
A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.
作者信息
Lew W, Wu H, Mendel D B, Escarpe P A, Chen X, Laver W G, Graves B J, Kim C U
机构信息
Gilead Sciences Inc., Foster City, CA 94404, USA.
出版信息
Bioorg Med Chem Lett. 1998 Dec 1;8(23):3321-4. doi: 10.1016/s0960-894x(98)00587-3.
PMID:9873727
Abstract
The synthesis and influenza neuraminidase inhibitory activity of a new series of C3-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.
摘要
描述了一系列新型C3-氮杂碳环神经氨酸酶抑制剂的合成及其流感神经氨酸酶抑制活性。带有3-戊基的类似物3c和3j表现出与1相当的甲型流感抑制活性。
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