Yoshiizumi K, Seko N, Nishimura N, Ikeda S, Yoshino K, Kondo H, Tanizawa K
Pharmaceutical Research Laboratories, Kanebo Ltd., Osaka, Japan.
Bioorg Med Chem Lett. 1998 Dec 1;8(23):3397-402. doi: 10.1016/s0960-894x(98)00625-8.
To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.
为了寻找选择性钾通道开放剂（PCOs），我们合成了几种3,5-二取代苯基氰基胍衍生物，并研究了它们的构效关系（SAR）。结果，我们发现了对降压活性具有1,1-二乙基丙基的选择性PCOs。
