Contrepois M, Bertin Y, Pohl P, Picard B, Girardeau J P
INRA, Laboratoire de Microbiologie, Centre de Recherches de Clermont-Ferrand-Theix, Saint-Genès-Champanelle, France.
Vet Microbiol. 1998 Nov;64(1):75-81. doi: 10.1016/s0378-1135(98)00253-3.
We investigated the clonal relationships among 41 enterotoxigenic (ETEC) or non-enterotoxigenic (NETEC) Escherichia coli strains producing the F17 a fimbriae isolated from diarrheic calves in France or Belgium in the early 1980s. Twenty-three of the 26 ETEC strains were highly clonally related, most of them with a O101:K32:H9-serotype. The NETEC strains were also divided in clonal subgroups, most of them with O101:H-serotype. The F17 a positive ETEC strains are no longer isolated from diarrheic calves in these countries. It is postulated that the use of a vaccine including O101, K32 and H9 antigens in addition to K99 (F5) explains the strongly reduced isolation of the O101:K32:H9, K99 (F5) E. coli clone.
我们研究了20世纪80年代初从法国或比利时腹泻犊牛中分离出的41株产F17 a菌毛的产肠毒素大肠杆菌（ETEC）或非产肠毒素大肠杆菌（NETEC）菌株之间的克隆关系。26株ETEC菌株中有23株具有高度的克隆相关性，其中大多数为O101:K32:H9血清型。NETEC菌株也被分为克隆亚组，其中大多数为O101:H血清型。在这些国家，腹泻犊牛中已不再分离到F17 a阳性ETEC菌株。据推测，除K99（F5）外，使用包含O101、K32和H9抗原的疫苗可以解释O101:K32:H9、K99（F5）大肠杆菌克隆的分离率大幅降低的原因。
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