Commentary: A revised view of local anesthetic action: what channel state is really stabilized?
作者信息
Scheuer T
机构信息
University of Washington, Seattle, Washington 98195-7280, USA.
出版信息
J Gen Physiol. 1999 Jan;113(1):3-6. doi: 10.1085/jgp.113.1.3.
Abstract
摘要
相似文献
1
Commentary: A revised view of local anesthetic action: what channel state is really stabilized?述评：局部麻醉作用的新观点：真正稳定的是何种通道状态？
J Gen Physiol. 1999 Jan;113(1):3-6. doi: 10.1085/jgp.113.1.3.
2
Open channel block and beyond.开放通道阻滞及其他情况。
J Physiol. 2010 Feb 15;588(Pt 4):553-4. doi: 10.1113/jphysiol.2009.183210.
3
Current concepts of the mechanism of action of local anesthetics.局部麻醉药作用机制的当前概念。
J Dent Res. 1981 Aug;60(8):1460-70. doi: 10.1177/00220345810600080904.
4
Mechanism of tetracaine block of cyclic nucleotide-gated channels.丁卡因对环核苷酸门控通道的阻断机制。
J Gen Physiol. 1997 Jan;109(1):3-14. doi: 10.1085/jgp.109.1.3.
5
Mutations affecting local anesthetic block of the nicotinic acetylcholine receptor ion channel.影响烟碱型乙酰胆碱受体离子通道局部麻醉阻滞的突变。
NIDA Res Monogr. 1991;111:28-44.
6
The role of inactivation in the cumulative blockage of voltage-dependent sodium channels by local anesthetics and antiarrythmics.失活在局部麻醉药和抗心律失常药对电压依赖性钠通道的累积阻滞中的作用。
Gen Physiol Biophys. 1984 Dec;3(6):517-20.
7
[Interaction of local anesthetics with model ion channels].[局部麻醉药与模型离子通道的相互作用]
Biofizika. 2002 May-Jun;47(3):506-11.
8
Structure-activity relations for frequency-dependent sodium channel block in nerve by local anesthetics.局部麻醉药对神经中频率依赖性钠通道阻滞的构效关系。
J Pharmacol Exp Ther. 1980 Apr;213(1):114-9.
9
Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by local anesthetics.局部麻醉药对[3H]蛙毒素A 20-α-苯甲酸酯与钠通道结合的抑制作用。
Mol Pharmacol. 1984 Mar;25(2):219-27.
10
Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5).酰胺类局部麻醉药可有效抑制人类双孔域背景钾通道TASK-2（KCNK5）。
J Pharmacol Exp Ther. 2003 Jul;306(1):84-92. doi: 10.1124/jpet.103.049809. Epub 2003 Mar 26.
引用本文的文献
1
Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics.局部麻醉药对电压门控钠离子通道变构调节的分子机制。
J Gen Physiol. 2010 Nov;136(5):541-54. doi: 10.1085/jgp.201010438. Epub 2010 Oct 11.
2
Bupivacaine blocks N-type inactivating Kv channels in the open state: no allosteric effect on inactivation kinetics.布比卡因可阻断处于开放状态的N型失活钾通道：对失活动力学无变构效应。
Biophys J. 2008 Dec;95(11):5138-52. doi: 10.1529/biophysj.108.130518. Epub 2008 Sep 12.
3
High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues.卤化丙泊酚类似物对电压门控性骨骼肌和神经元钠通道的高亲和力阻断作用。
Br J Pharmacol. 2008 Sep;155(2):265-75. doi: 10.1038/bjp.2008.255. Epub 2008 Jun 23.
4
Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding.对处于关闭、开放和快速失活构象的电压门控钠通道的孔结构进行建模，揭示了1型位点毒素和局部麻醉药结合的细节。
J Mol Model. 2006 Sep;12(6):813-22. doi: 10.1007/s00894-005-0066-y. Epub 2006 Mar 1.
5
Block of voltage-operated sodium channels by 2,6-dimethylphenol, a structural analogue of lidocaine's aromatic tail.2,6 - 二甲基苯酚（利多卡因芳香尾部的结构类似物）对电压门控钠通道的阻断作用
Br J Pharmacol. 2002 Sep;137(2):285-93. doi: 10.1038/sj.bjp.0704854.
6
Structural requirements for voltage-dependent block of muscle sodium channels by phenol derivatives.苯酚衍生物对肌肉钠通道电压依赖性阻滞的结构要求
Br J Pharmacol. 2001 Apr;132(8):1916-24. doi: 10.1038/sj.bjp.0704024.
7
Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel.细胞质多胺作为电压门控钠通道的渗透性阻滞剂和调节剂。
Biophys J. 2001 Mar;80(3):1262-79. doi: 10.1016/S0006-3495(01)76102-4.
8
Selective block of late Na(+) current by local anaesthetics in rat large sensory neurones.局部麻醉药对大鼠大型感觉神经元晚期钠电流的选择性阻断
Br J Pharmacol. 2000 Apr;129(8):1617-26. doi: 10.1038/sj.bjp.0703261.
本文引用的文献
1
Effects of calcium ions and local anesthetics on electrical properties of Purkinje fibres.钙离子和局部麻醉药对浦肯野纤维电特性的影响。
J Physiol. 1955 Sep 28;129(3):568-82. doi: 10.1113/jphysiol.1955.sp005379.
2
The position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channels.利多卡因阻断电压门控性Na+通道期间快速失活门的位置。
J Gen Physiol. 1999 Jan;113(1):7-16. doi: 10.1085/jgp.113.1.7.
3
Slow inactivation does not affect movement of the fast inactivation gate in voltage-gated Na+ channels.缓慢失活并不影响电压门控钠通道中快速失活门的移动。
J Gen Physiol. 1998 Jan;111(1):83-93. doi: 10.1085/jgp.111.1.83.
4
Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels.局部麻醉药作为变构门控的效应剂。利多卡因对失活缺陷型大鼠骨骼肌钠通道的影响。
J Clin Invest. 1996 Dec 15;98(12):2874-86. doi: 10.1172/JCI119116.
5
Movement of the Na+ channel inactivation gate during inactivation.失活过程中Na⁺通道失活门的运动。
J Biol Chem. 1996 Nov 29;271(48):30971-9. doi: 10.1074/jbc.271.48.30971.
6
Na+ channels must deactivate to recover from inactivation.钠离子通道必须失活才能从失活状态恢复。
Neuron. 1994 Apr;12(4):819-29. doi: 10.1016/0896-6273(94)90335-2.
7
On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain.关于心脏钠通道利多卡因受体的分子本质。通过α亚基III-IV结构域间的改变对阻滞作用的修饰。
Circ Res. 1995 Sep;77(3):584-92. doi: 10.1161/01.res.77.3.584.
8
Lidocaine block of cardiac sodium channels.利多卡因对心脏钠通道的阻滞作用。
J Gen Physiol. 1983 May;81(5):613-42. doi: 10.1085/jgp.81.5.613.
9
Antiarrhythmic agents: the modulated receptor mechanism of action of sodium and calcium channel-blocking drugs.抗心律失常药物：钠通道阻滞剂和钙通道阻滞剂的受体调节作用机制
Annu Rev Pharmacol Toxicol. 1984;24:387-423. doi: 10.1146/annurev.pa.24.040184.002131.
10
Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons.乌贼轴突中季铵离子注入引起的钾离子电导失活及相关现象。
J Gen Physiol. 1969 Nov;54(5):553-75. doi: 10.1085/jgp.54.5.553.
Zotero 插件