Makkes P C, van Velzen S K, van den Hooff A
Oral Surg Oral Med Oral Pathol. 1978 Jul;46(1):131-44. doi: 10.1016/0030-4220(78)90447-4.
Polyethylene tubes closed at both ends and with four perforations in the side walls were filled either with isologous muscle tissue or with formaldehyde-fixed or glutaraldehyde-fixed isologous tissue, and then implanted subcutaneously in rats. As controls, tubes with solutions of the fixatives were implanted. When cell reaction in the tissues surrounding the differently filled tubes was examined, the reaction to untreated necrotic tissue was found to be the least severe.