Bower J E, Kemeny M E, Taylor S E, Fahey J L
Department of Psychology, University of California, Los Angeles, USA.
J Consult Clin Psychol. 1998 Dec;66(6):979-86. doi: 10.1037//0022-006x.66.6.979.
This study investigated whether finding meaning in response to an HIV-related stressor was associated with changes in immune status and health. Forty HIV-seropositive men who had recently experienced an AIDS-related bereavement completed interviews assessing cognitive processing and finding meaning after the loss and provided blood samples for a 2- to 3-year follow-up. AIDS-related mortality over an extended follow-up was determined from death certificates. As predicted, men who engaged in cognitive processing were more likely to find meaning from the loss. Furthermore, men who found meaning showed less rapid declines in CD4 T cell levels and lower rates of AIDS-related mortality (all ps < .05), independent of health status at baseline, health behaviors, and other potential confounds. These results suggest that positive responses to stressful events, specifically the discovery of meaning, may be linked to positive immunologic and health outcomes.
本研究调查了从与艾滋病相关的应激源中寻找意义是否与免疫状态和健康状况的变化有关。40名近期经历过与艾滋病相关丧亲之痛的HIV血清阳性男性完成了访谈，评估了丧失后的认知加工和寻找意义的情况，并提供血样用于2至3年的随访。通过死亡证明确定长期随访中的艾滋病相关死亡率。正如预期的那样，进行认知加工的男性更有可能从丧失中找到意义。此外，找到意义的男性CD4 T细胞水平下降较慢，艾滋病相关死亡率较低（所有p值均<0.05），这与基线健康状况、健康行为及其他潜在混杂因素无关。这些结果表明，对应激事件的积极反应，特别是意义的发现，可能与积极的免疫和健康结果相关。
