Villares J, Faucheux B, Herrero M T, Obeso J A, Duyckaerts C, Hauw J J, Agid Y, Hirsch E C
INSERM U289, Hôpital de la Salpêtrière, Paris, France.
Exp Neurol. 1998 Nov;154(1):146-56. doi: 10.1006/exnr.1998.6933.
Since EGF is known to protect and stimulate the activity of dopaminergic neurons, an autoradiographic study of [125I]EGF binding sites was performed in the striatum and pallidal complex in parkinsonian syndromes. The analysis was performed on postmortem brain tissues of three control subjects, three patients with Parkinson's disease, and three patients with progressive supranuclear palsy, another parkinsonian syndrome in which dopaminergic neurons also degenerate. Since all six patients had been treated with L-Dopa, we also analyzed the effects of this drug in an animal model of Parkinson's disease. Quantitative analysis of [125I]EGF binding was performed on the brains of three control monkeys, nine monkeys rendered parkinsonian by MPTP intoxication, three of which were treated with L-Dopa. An increased density of [125I]EGF binding was observed at anterior levels in the dorsal striatum, but not in the pallidum, of patients with Parkinson's disease and progressive supranuclear palsy. [125I]EGF binding was unchanged in parkinsonian monkeys whether or not they had been treated with L-Dopa. The data suggest an increased expression of EGFRs in the striatum in chronic parkinsonian syndromes but not in acute models of the disease.
由于已知表皮生长因子（EGF）可保护并刺激多巴胺能神经元的活性，因此在帕金森综合征的纹状体和苍白球复合体中进行了一项关于[125I]EGF结合位点的放射自显影研究。分析对象为三名对照受试者、三名帕金森病患者以及三名进行性核上性麻痹患者的死后脑组织，进行性核上性麻痹是另一种帕金森综合征，其中多巴胺能神经元也会退化。由于所有六名患者均接受过左旋多巴治疗，我们还在帕金森病动物模型中分析了这种药物的作用。对三只对照猴子、九只因1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）中毒而患帕金森病的猴子（其中三只接受了左旋多巴治疗）的大脑进行了[125I]EGF结合的定量分析。在帕金森病和进行性核上性麻痹患者的背侧纹状体前部水平观察到[125I]EGF结合密度增加，但在苍白球中未观察到。无论是否接受过左旋多巴治疗，帕金森病猴子的[125I]EGF结合均未改变。数据表明，在慢性帕金森综合征的纹状体中表皮生长因子受体（EGFRs）表达增加，但在该疾病的急性模型中未增加。
