3-甲氧基甲基头孢菌素前药的合成及药代动力学特征
Synthesis and pharmacokinetic profile of 3-methoxymethyl cephalosporin prodrugs.
作者信息
Jung M H, Cho K W, Park J G, Kim Y H
机构信息
Korea Research Institute of Chemical Technology, Yusong, Taejon, Korea.
出版信息
Arch Pharm Res. 1998 Oct;21(5):559-64. doi: 10.1007/BF02975375.
PMID:9875495
Abstract
Preparation and biological activity of prodrug-type 3-methoxymethyl cephalosporins were described. From the mixtures, R- and S-prodrugs were separated and their absolute configurations were determined, and also their bioavailability was investigated.
摘要
描述了前药型3-甲氧基甲基头孢菌素的制备及其生物活性。从混合物中分离出R-和S-前药，测定了它们的绝对构型，并研究了它们的生物利用度。
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