硫酸头孢匹罗在老年人中的药代动力学研究。

Study of the pharmacokinetics of cefpirome sulphate in the elderly.

作者信息

Sugihara H, Narita N, Takatsu R, Horiuchi M, Yonenami K, Hotta M, Shibahara K, Kamo T, Negishi Y

机构信息

Second Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

出版信息

J Clin Pharm Ther. 1998 Oct;23(5):375-9. doi: 10.1046/j.1365-2710.1998.00176.x.

DOI:10.1046/j.1365-2710.1998.00176.x

PMID:9875686

Abstract

OBJECTIVE

To determine the appropriate method of administration of the cephem antibiotic cefpirome sulphate in elderly patients.

METHOD

We studied cefpirome's pharmacokinetics in patients with urinary tract infections. Patients received cefpirome sulphate 0.5 g by intravenous drip infusion over 30 mins.

RESULTS

Patients with a creatinine clearance rate (Ccr) of 80 ml/min had an AUC of 96.7 microg.h/ml and a T1/2 of 2.36 h, whereas those with Ccr of 40-80 ml/min had an AUC of 172.0 microg.h/ml and a T1/2 of 3.45 h and those with Ccr of < 40 ml/min had an AUC of 152 microg.h/ ml and a T1/2 of 4.86 h.

CONCLUSION

These results indicate that decreased kidney function can cause increases in the AUC and T1/2 of cefpirome. Thus in elderly patients and perhaps also in other patients with decreased kidney function, cefpirome should be administered at an initial dose of 0.5 g.

摘要

目的

确定老年患者中头孢菌素类抗生素硫酸头孢匹罗的合适给药方法。

方法

我们研究了硫酸头孢匹罗在尿路感染患者中的药代动力学。患者接受0.5g硫酸头孢匹罗，在30分钟内静脉滴注。

结果

肌酐清除率（Ccr）为80ml/分钟的患者的曲线下面积（AUC）为96.7μg·h/ml，半衰期（T1/2）为2.36小时；Ccr为40 - 80ml/分钟的患者的AUC为172.0μg·h/ml，T1/2为3.45小时；Ccr小于40ml/分钟的患者的AUC为152μg·h/ml，T1/2为4.86小时。