Nussenzweig M C
Laboratory of Molecular Immunology, The Rockefeller University, Howard Hughes Medical Institute, New York, New York 10021, USA.
Cell. 1998 Dec 23;95(7):875-8. doi: 10.1016/s0092-8674(00)81711-0.
Secondary antigen receptor gene recombination occurs in developing lymphocytes, and in more mature T and B cells. In the developing lymphocyte, "editing" occurs in response to receptor ligation by autoantigens. As a result of receptor editing, anti-self-reactive cells are converted to non-self-reactive cells, and self-reactive clones are thereby salvaged before negative selection. This antigen-induced change in the receptor specificity was not foreseen in the clonal selection theory. However, editing could be incorporated into the clonal selection theory by limiting receptor selection to a specific stage in lymphocyte development that precedes cellular selection as suggested by Jerne (1971). We know much less about the origin, regulation, or function of V(D)J recombination in mature lymphocytes. Nevertheless, antigen-induced receptor selection is likely to play an important role in shaping immune responses.
二次抗原受体基因重组发生在发育中的淋巴细胞以及更成熟的T细胞和B细胞中。在发育中的淋巴细胞中，“编辑”会因自身抗原与受体的连接而发生。作为受体编辑的结果，抗自身反应性细胞会转变为非自身反应性细胞，从而在阴性选择之前挽救自身反应性克隆。克隆选择理论并未预见到这种由抗原诱导的受体特异性变化。然而，正如耶尔恩（1971年）所建议的，通过将受体选择限制在淋巴细胞发育中先于细胞选择的特定阶段，编辑可以被纳入克隆选择理论。我们对成熟淋巴细胞中V(D)J重组的起源、调控或功能了解得要少得多。尽管如此，抗原诱导的受体选择可能在塑造免疫反应中发挥重要作用。
