Evaluation of dosage forms. IV. Studies on commercial phenylbutazone tablet dosage forms.
作者信息
Razdan B, Paradkar A R
机构信息
Department of Pharmaceutical Sciences, Birla Institute of Technology, Ranchi, India.
出版信息
Drug Dev Ind Pharm. 1998 Jul;24(7):599-604. doi: 10.3109/03639049809082360.
PMID:9876503
Abstract
In order to determine the feasibility of dissolution-dialysis as a suitable technique for in vitro evaluation, studies on commercial phenylbutazone tablets were carried out. Although disintegration time and dissolution parameters did not give a true indication of bioavailability, an excellent correlation was obtained between the dialysis rate constant (K) and various pharmacokinetic parameters obtained from bioavailability studies on human volunteers.
摘要
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