Palmieri G F, Wehrlé P, Martelli S
Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
Drug Dev Ind Pharm. 1998 Jul;24(7):653-60. doi: 10.3109/03639049809082367.
The possibility of obtaining inclusion complexes between lonidamine and beta- or hydroxypropyl-beta-cyclodextrin have been evaluated by phase solubility diagram, differential scanning calorimetry (DSC), and x-ray diffractometry. The applied complexation methods were spray-drying, kneading, and solid dispersion. DSC and x-ray analyses of the powders revealed an external interaction between lonidamine and cyclodextrins. Dissolution profiles of the obtained powders were also studied to define the most appropriate preparation method and molar ratio to use in attempts to increase lonidamine water solubility.
已通过相溶解度图、差示扫描量热法（DSC）和X射线衍射法评估了氯尼达明与β-或羟丙基-β-环糊精之间形成包合物的可能性。应用的络合方法有喷雾干燥、捏合和固体分散。对粉末进行的DSC和X射线分析显示氯尼达明与环糊精之间存在外部相互作用。还研究了所得粉末的溶出曲线，以确定在试图提高氯尼达明水溶性时最适合的制备方法和摩尔比。
