Dangi J S, Vyas S P, Dixit V K
Department of Pharmaceutical Sciences, Doctor Harisingh Gour Vishwavidyalaya, Sagar, India.
Drug Dev Ind Pharm. 1998 Jul;24(7):681-4. doi: 10.3109/03639049809082372.
The present study revealed that the solubilization of a poorly soluble drug, Amphotericin-B (AmB) can be improved by lipid-bile salt mixed micelles and it was also noted that mixed micellar systems are thermodynamically stable relative to micellar systems. It was observed that the degradation or precipitation of AmB was significantly reduced when stored at 8 degrees C. The mixed micellar systems composed of sodium desoxycholate with monoolein increased the solubilization of AmB by more than seven-fold as compared to nonmicellar systems.
本研究表明，难溶性药物两性霉素B（AmB）的增溶作用可通过脂质 - 胆盐混合胶束得到改善，并且还注意到，相对于胶束系统，混合胶束系统在热力学上是稳定的。观察到，当在8摄氏度储存时，AmB的降解或沉淀显著减少。由去氧胆酸钠与单油酸甘油酯组成的混合胶束系统使AmB的增溶作用比非胶束系统提高了七倍以上。
