Wilson K E, Potter A
Procter and Gamble Pharmaceuticals, Process Development Department, Norwich, NY 13815, USA.
Drug Dev Ind Pharm. 1998 Nov;24(11):1017-24. doi: 10.3109/03639049809089945.
An investigation of four different tablet strength tests was carried out on four different placebo formulations (differing in Avicel: Pharmatose ratios). The results analysis compared fatigue failure, work of failure, and impact failure to diametrical compression measurements (hardness). The impact results clearly show how different formulations can have the same hardness, yet their impact resistance can vary by as much as 200%. The impact test used in this work and other tests described are useful in tablet development to understand, compare, and mitigate tablet breakage during subsequent unit operations.
对四种不同的安慰剂制剂（微晶纤维素：药用糖比例不同）进行了四种不同片剂强度测试的研究。结果分析将疲劳失效、失效功和冲击失效与直径压缩测量值（硬度）进行了比较。冲击结果清楚地表明，不同的制剂如何能够具有相同的硬度，但其抗冲击性却可能相差高达200%。这项工作中使用的冲击测试以及所描述的其他测试，对于片剂开发中理解、比较和减轻后续单元操作过程中的片剂破损很有用。
