Tuleu C, Chaumeil J C
Laboratoire de Pharmacotechnie et de Dermopharmacie, Faculté des Sciences Pharmaceutiques et Biologiques Paris, Paris, France.
Drug Dev Ind Pharm. 1998 May;24(5):423-9. doi: 10.3109/03639049809085639.
The method of compresso-rheology with an Instron 5567 was used for flow assessment of wet powder mass in order to improve its formulation. In our experiments, the method was efficient for selection of the excipient (Avicel CL611) able to improve the extrusion behavior of the high-dose wet powder mass. The method also allowed the determination of the minima and maxima of the wetting agent volume necessary to identify the correct moisture content for extrusion (20%). The results were not discriminative for the choice of the Avicel CL611 amount in the formulae even if an average amount necessary to improve extrudability of the active ingredient could have been estimated at about 10%. Nevertheless, this method appeared to be a rapid and easy small-scale method for studying wet powder mass, cause only a few grams of solids are required, this rheometer should prove useful in formulation research.
为改进湿粉末物料的配方，采用配备Instron 5567的压缩流变学方法对其流动性进行评估。在我们的实验中，该方法对于选择能够改善高剂量湿粉末物料挤出行为的辅料（微晶纤维素CL611）很有效。该方法还能确定为挤出确定正确水分含量（20%）所需润湿剂体积的最小值和最大值。即使可以估计出提高活性成分可挤出性所需的平均用量约为10%，但该结果对于配方中微晶纤维素CL611用量的选择并无区分性。尽管如此，该方法似乎是一种快速简便的小规模研究湿粉末物料的方法，因为仅需几克固体，这种流变仪在配方研究中应会证明很有用。
