Khan G M, Jiabi Z
Zhong Kun Pharmaceutical Research Institute, School of Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
Drug Dev Ind Pharm. 1998 May;24(5):455-62. doi: 10.3109/03639049809085643.
Solid dispersions of ibuprofen (IBF) were prepared by solvent evaporation method using polyethylene glycol 10000 (PEG), talc, and PEG-talc as dispersion carriers. The drug-carrier(s) interactions in the solid state were investigated using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and x-ray diffraction analysis. Interactions in the solution were studied by performing dissolution experiments. No important and well-defined chemical interaction was found between the ingredients. The increase in the IBF dissolution rate from the solid dispersions with the carriers used in this study could be attributed to several factors such as improved wettability, local solubilization, and drug particle size reduction.
采用溶剂蒸发法，以聚乙二醇10000（PEG）、滑石粉和PEG-滑石粉作为分散载体，制备了布洛芬（IBF）固体分散体。利用扫描电子显微镜（SEM）、差示扫描量热法（DSC）和X射线衍射分析，研究了固态下药物与载体之间的相互作用。通过进行溶出实验，研究了溶液中的相互作用。未发现各成分之间存在重要且明确的化学相互作用。本研究中使用载体的IBF固体分散体溶出速率的提高可归因于几个因素，如润湿性改善、局部增溶和药物粒径减小。
