Ghosh L K, Ghosh N C, Chatterjee M, Gupta B K
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Drug Dev Ind Pharm. 1998 May;24(5):473-7. doi: 10.3109/03639049809085645.
To improve the bioavailability of ibuprofen, a thorough preformulation trial was undertaken. As a part of these studies, particle size of the drug, solubility-pH profile, and pH-partition coefficient profile were studied. The probability of improving solubility by solid dispersion technique was also investigated. The effects of different binding agents and incorporation of various proportions of sodium lauryl sulfate on the release rate of ibuprofen were also studied. The in vitro release profiles of the developed tablets showed superiority over the popular marketed tablets.
为提高布洛芬的生物利用度，进行了全面的制剂前试验。作为这些研究的一部分，对药物的粒径、溶解度-pH曲线以及pH-分配系数曲线进行了研究。还研究了采用固体分散技术提高溶解度的可能性。此外，还研究了不同粘合剂以及不同比例十二烷基硫酸钠的加入对布洛芬释放速率的影响。所研制片剂的体外释放曲线显示出优于市售畅销片剂。
