Salter D W, Payne W, Crittenden L B, Fadly A M
Department of Microbiology, Michigan State University, East Lansing 48824, USA.
Avian Dis. 1998 Oct-Dec;42(4):781-6.
The ALVA11 germline insert in chickens is a defective subgroup A avian leukosis virus (ALV) proviral insert that expresses a low-to-moderate level of subgroup A ALV envelope glycoprotein. Chicks carrying or lacking ALVA11 were evaluated for response to challenge by RPL-42, a pathogenic field strain of subgroup A ALV, by either exposure to chicks shedding RPL-42 or direct injection with various doses of RPL-42. Chicks carrying ALVA11 were significantly more resistant, as measured by infectious virus and viral antibody status, to horizontal infection and direct injection of RPL-42 than chicks lacking ALVA11.
鸡体内的ALVA11种系插入是一种有缺陷的A亚群禽白血病病毒（ALV）前病毒插入，它表达低至中等水平的A亚群ALV包膜糖蛋白。通过接触排出RPL-42的雏鸡或直接注射不同剂量的RPL-42，评估携带或不携带ALVA11的雏鸡对A亚群ALV致病野毒株RPL-42攻击的反应。通过感染性病毒和病毒抗体状态测定，携带ALVA11的雏鸡比不携带ALVA11的雏鸡对RPL-42的水平感染和直接注射具有显著更高的抵抗力。
