Henson D A, Nieman D C, Parker J C, Rainwater M K, Butterworth D E, Warren B J, Utter A, Davis J M, Fagoaga O R, Nehlsen-Cannarella S L
Department of Biology, Appalachian State University, Boone, North Carolina 28608, USA.
Int J Sports Med. 1998 Nov;19(8):574-80. doi: 10.1055/s-2007-971962.
This randomized, double-blind, placebo-controlled study examined the influence of 6% carbohydrate ingestion on hormonal and lymphocyte proliferative responses (5 total samples over 9 hours) to 2.5 h of high-intensity running by 30 experienced marathon runners. The T-cell response differed between groups, with the placebo group exhibiting a greater increase immediately post-run and greater decrease at 3 h of recovery. No group differences were observed for Con A-, PHA-, or PWM-induced lymphocyte proliferation. However, when PHA was adjusted per T-cell, group differences were observed, highlighted by a decrease in the placebo group immediately post-run. Glucose and cortisol responses differed between groups, with glucose lower and cortisol higher in the placebo group immediately post-run. Post-run glucose correlated negatively with postrun cortisol (r=-0.670, P< 0.001) and epinephrine (r=-0.540, P=0.002). Post-run cortisol also correlated negatively with total lymphocytes and T-cells at 1.5 hours (r=-0.429, P=0.018 and r=-0.424, P=0.019, respectively) and 3 hours (r=-0.566, P=0.001 and r=-0.523, P=0.003, respectively) of recovery. The pre- to post-run change in glucose correlated to the same changes in PHA/T-cell (r=0.456, P=0.011). The data support an interactive effect of carbohydrate ingestion on plasma glucose and cortisol. The data support an interactive effect of carbohydrate ingestion on plasma glucose and cortisol, T-cell trafficking, and cell-adjusted PHA-induced lymphocyte proliferation following long endurance running.
这项随机、双盲、安慰剂对照研究，考察了30名经验丰富的马拉松运动员摄入6%碳水化合物对高强度跑步2.5小时后激素及淋巴细胞增殖反应（9小时内共采集5次样本）的影响。两组之间T细胞反应存在差异，安慰剂组在跑步后即刻显示出更大幅度的增加，而在恢复3小时后出现更大幅度的下降。在伴刀豆球蛋白A、植物血凝素或美洲商陆有丝分裂原诱导的淋巴细胞增殖方面，未观察到组间差异。然而，当按T细胞调整植物血凝素时，观察到了组间差异，突出表现为安慰剂组在跑步后即刻出现下降。两组之间葡萄糖和皮质醇反应存在差异，安慰剂组在跑步后即刻血糖较低而皮质醇较高。跑步后血糖与跑步后皮质醇（r=-0.670，P<0.001）和肾上腺素（r=-0.540，P=0.002）呈负相关。跑步后皮质醇在恢复1.5小时（分别为r=-0.429，P=0.018和r=-0.424，P=0.019）和3小时（分别为r=-0.566，P=0.001和r=-0.523，P=0.003）时也与总淋巴细胞和T细胞呈负相关。跑步前后葡萄糖的变化与植物血凝素/T细胞的相同变化相关（r=0.456，P=0.011）。数据支持碳水化合物摄入对血糖和皮质醇的交互作用。数据支持碳水化合物摄入对长时间耐力跑步后的血糖和皮质醇、T细胞运输以及细胞调整的植物血凝素诱导的淋巴细胞增殖具有交互作用。
