Asayama K, Hayashi K, Hayashibe H, Uchida N, Nakane T, Kodera K, Nakazawa S
Department of Pediatrics, Yamanashi Medical University, Nakakomagun, Japan.
Int J Obes Relat Metab Disord. 1998 Dec;22(12):1209-16. doi: 10.1038/sj.ijo.0800748.
To determine the clinical utility of a new age-adjusted measure of body fat distribution (based on waist and hip circumferences) and stature, in relation to biochemical complications in obese children.
Cross-sectional, clinical study. The formula to calculate the common standard deviation score (SDS) of waist-to-hip ratio/height (WHR/Ht) was obtained from the data of control children. The relationship between WHR/Ht SDS, as the age-adjusted measure, in obese children and their clinical laboratory data was evaluated.
Outpatient obese Japanese children (102 boys and 75 girls) and control children (508 boys and 549 girls), ranging in age from 6-15 y.
Height, body weight, waist girth, hip girth, triceps and subscapular skinfold thicknesses, as anthropometric measures. Percent overweight, percent body fat, waist girth, WHR and WHR/Ht SDS as criteria for obesity. Clinical laboratory analyses for fasting blood samples of obese children.
The WHR/Ht SDS closely correlated with age in obese children, thus reflecting the progress of abdominal obesity during growth. The obese boys were more hyperlipidaemic than the girls were, although the percent overweight was similar in both genders. The percent overweight, percent body fat, waist girth and WHR/Ht SDS all correlated well with triglyceride (TG), alanine aminotransferase (ALT) and insulin in boys, whereas only waist girth and WHR/Ht SDS showed a close correlation with TG and insulin in girls. The obese subjects were subdivided according to the number of abnormal values observed in TG, ALT and insulin. For obese boys, all five indices of obesity were higher in the groups with complications than in the group without. In the girls, only the WHR/Ht SDS constantly differed between subgroups. WHR/Ht SDS most obviously distinguished the groups with complications from the other group with a wide margin of difference (2-fold in boys and > 2-fold in girls) in the mean values.
The WHR/Ht SDS can serve as an index predicting the occurrence of biochemical complications in obese children ranging from the age of 6-15 y.
确定一种新的根据年龄调整的身体脂肪分布测量方法（基于腰围和臀围）及身高与肥胖儿童生化并发症之间的临床实用性。
横断面临床研究。从对照儿童的数据中得出计算腰臀比/身高（WHR/Ht）共同标准差评分（SDS）的公式。评估肥胖儿童中作为年龄调整测量指标的WHR/Ht SDS与其临床实验室数据之间的关系。
6至15岁的日本门诊肥胖儿童（102名男孩和75名女孩）以及对照儿童（508名男孩和549名女孩）。
身高、体重、腰围、臀围、肱三头肌和肩胛下皮褶厚度，作为人体测量指标。超重百分比、体脂百分比、腰围、腰臀比和WHR/Ht SDS作为肥胖标准。对肥胖儿童的空腹血样进行临床实验室分析。
肥胖儿童的WHR/Ht SDS与年龄密切相关，从而反映了生长过程中腹部肥胖的进展情况。尽管男女超重百分比相似，但肥胖男孩的血脂异常情况比女孩更严重。超重百分比、体脂百分比、腰围和WHR/Ht SDS在男孩中均与甘油三酯（TG）、丙氨酸转氨酶（ALT）和胰岛素密切相关，而在女孩中只有腰围和WHR/Ht SDS与TG和胰岛素密切相关。根据在TG、ALT和胰岛素中观察到的异常值数量对肥胖受试者进行细分。对于肥胖男孩，有并发症组的所有五项肥胖指标均高于无并发症组。在女孩中，只有WHR/Ht SDS在各亚组之间持续存在差异。WHR/Ht SDS最明显地区分了有并发症组与其他组，两组平均值差异幅度很大（男孩为2倍，女孩大于2倍）。
WHR/Ht SDS可作为预测6至15岁肥胖儿童生化并发症发生情况的指标。
