Kishimoto R A, Eveland W C
Can J Microbiol. 1976 Sep;22(9):1307-11. doi: 10.1139/m76-193.
The interaction between two strains of Pseudomonas pseudomallei of different virulence with normal and immune rabbit peritoneal macrophages was compared in vitro. Phagocytic activity of macrophages and bacterial survival within macrophages were dependent upon the virulence of the bacterial strain and the immune status of the macrophages. Virulent bacteria were more resistant than the less virulent strain to phagocytosis and destruction. Immune macrophages were more phagocytic and bactericidal than normal macrophages. Specific immune serum facilitated ingestion and destruction of bacteria by both normal and immune macrophages.
在体外比较了两株毒力不同的类鼻疽假单胞菌与正常及免疫家兔腹膜巨噬细胞之间的相互作用。巨噬细胞的吞噬活性以及细菌在巨噬细胞内的存活情况取决于细菌菌株的毒力和巨噬细胞的免疫状态。有毒力的细菌比毒力较弱的菌株更能抵抗吞噬和破坏。免疫巨噬细胞比正常巨噬细胞具有更强的吞噬和杀菌能力。特异性免疫血清促进正常和免疫巨噬细胞对细菌的摄取和破坏。
