Estler C J, Ammon H P, Herzog C
Psychopharmacology (Berl). 1978 Jul 6;58(2):161-6. doi: 10.1007/BF00426900.
A comparative study of the effects of a single dose of caffeine (50 microgram/g s.c.) and of 6-weeks treatment with 150 microgram/g p.o. caffeine/day on swimming capacity and resistance to cold exposure was performed in mice. In contrast to acute treatment, chronic treatment with caffeine greatly reduced the swimming capacity and diminished the ability of the animals to withstand cold stress. It could be shown by indirect means that the detrimental effect of the prolonged treatment with caffeine was not due to an accumulation of toxic levels of caffeine. Motor coordination was unaffected. There was no deficiency of metabolic substrates, since glycogen, and fat stores, and blood glucose, and fatty acid levels were not lower than in control animals. It is proposed that caffeine may interfere with the animals' ability to mobilize and spend metabolic substrates for energy requirements of skeletal muscle.
对小鼠进行了一项比较研究，观察单次皮下注射50微克/克咖啡因和连续6周每天口服150微克/克咖啡因对游泳能力和耐寒能力的影响。与急性处理不同，咖啡因慢性处理大大降低了游泳能力，并削弱了动物抵御冷应激的能力。间接证据表明，咖啡因长期处理的有害作用并非由于咖啡因毒性水平的积累。运动协调性未受影响。代谢底物不存在缺乏，因为糖原、脂肪储备、血糖和脂肪酸水平均不低于对照动物。有人提出，咖啡因可能会干扰动物动员和利用代谢底物以满足骨骼肌能量需求的能力。
