神经肽FF增强对苯丙胺的行为敏化作用，并改变内侧前额叶皮质中神经递质的水平。
Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex.
作者信息
Chen J C, Li J Y, Liang K W, Huang Y K
机构信息
Laboratory of Neuropharmacology, Department of Pharmacology, Chang-Gung University, Tao-Yuan 333, Taiwan.
出版信息
Brain Res. 1999 Jan 16;816(1):220-4. doi: 10.1016/s0006-8993(98)01108-1.
We have demonstrated that chronic administration of neuropeptide FF (NPFF) into the lateral ventricle potentiated the behavioral sensitization to amphetamine. Further, the treatment with NPFF decreased the levels of serotonin, and increased the glutamate and GABA content in the medial prefrontal cortex of amphetamine-sensitized rats. The results suggest that NPFF may modulate the neuronal process of amphetamine addiction.
我们已经证明，向侧脑室慢性注射神经肽FF（NPFF）可增强对苯丙胺的行为敏化作用。此外，用NPFF治疗可降低血清素水平，并增加苯丙胺敏化大鼠内侧前额叶皮质中的谷氨酸和γ-氨基丁酸含量。结果表明，NPFF可能调节苯丙胺成瘾的神经元过程。
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