Maruniak J A, Bronson F H
Endocrinology. 1976 Oct;99(4):963-9. doi: 10.1210/endo-99-4-963.
Five experiments consistently demonstrated the existence of a factor(s) in the urine of female mice which stimulates gonadotropin secretion in male mice. The factor, presumably a priming pheromone, is not found in the urine of intact or castrated males nor is it in the urine of female hamsters. Furthermore, the potency of female mouse urine is apparently independent of ovarian state. In the response of the male, the release of LH is more dramatic than that of Fsh. as little as 10 min of exposure to female urine produced significantly elevated LH levels at 30 min. Finally, the male's responsiveness is largely, and possibly entirely, independent of his sexual experience. These results are discussed within the framework of a two-way pheromonal system by way of which urinary factors of both sexes modulate gonadotropin and gonadal hormone secretion in the opposite sex.
五项实验一致证明，雌性小鼠尿液中存在一种因子，可刺激雄性小鼠的促性腺激素分泌。该因子可能是一种启动信息素，在完整或阉割雄性小鼠的尿液中未发现，雌性仓鼠的尿液中也没有。此外，雌性小鼠尿液的效力显然与卵巢状态无关。在雄性的反应中，促黄体生成素（LH）的释放比促卵泡生成素（Fsh）更显著。暴露于雌性尿液仅10分钟，30分钟时促黄体生成素水平就显著升高。最后，雄性的反应能力在很大程度上，甚至可能完全独立于其性经验。本文在双向信息素系统的框架内讨论了这些结果，通过该系统，两性的尿液因子调节异性的促性腺激素和性腺激素分泌。
