Wojtowicz A, Yamauchi M, Sotowski R, Ostrowski K
Department of Transplantology, Medical University in Warsaw, Poland.
J Periodontal Res. 1998 Nov;33(8):486-90. doi: 10.1111/j.1600-0765.1998.tb02348.x.
The osteopetrotic mib mutation in rats causes defects in the skeletal bone tissue in young animals. These defects, i.e. slow bone remodelling, changes in both crystallinity and mineral content, are transient and undergo normalization, even without any treatment in 6-wk-old animals. Treatment with CSF-1 (colony stimulating factor-1) accelerates the normalization process in skeletal bones. The periodontal tissues around the apices of incisors show abnormalities caused by the slow remodelling process of the mandible bone tissue, the deficiency of osteoclasts and their abnormal morphology, as well as the disorganization of periodontal ligament fibres. In contrast to the skeletal tissues, these abnormalities would not undergo spontaneous normalization. Under treatment with colony stimulating factor 1 (CSF-1), the primitive bone trabeculae of mandible are resorbed and the normalization of the number of osteoclasts and their cytology occurs. The organization of the periodontal ligament fibres is partially restored, resembling the histological structure of the normal one.
大鼠的骨石化性mib突变会导致幼年动物骨骼骨组织出现缺陷。这些缺陷，即骨重塑缓慢、结晶度和矿物质含量的变化，是暂时的，并且会恢复正常，即使在6周龄的动物中不进行任何治疗也是如此。用集落刺激因子-1（CSF-1）治疗可加速骨骼的正常化进程。切牙根尖周围的牙周组织显示出由下颌骨组织重塑过程缓慢、破骨细胞缺乏及其形态异常以及牙周韧带纤维紊乱引起的异常。与骨骼组织不同，这些异常不会自发恢复正常。在用集落刺激因子1（CSF-1）治疗后，下颌骨的原始骨小梁被吸收，破骨细胞数量及其细胞学恢复正常。牙周韧带纤维的排列部分恢复，类似于正常组织的组织结构。
