2-甲氧基雌二醇是17β-雌二醇的内源性代谢产物，可抑制脂肪细胞增殖。
2-Methoxyestradiol, an endogenous metabolite of 17beta-estradiol, inhibits adipocyte proliferation.
作者信息
Picó C, Puigserver P, Oliver P, Palou A
机构信息
Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain.
出版信息
Mol Cell Biochem. 1998 Dec;189(1-2):1-7. doi: 10.1023/a:1006835124149.
The effects of 2-methoxyestradiol (2ME), a naturally occurring mammalian metabolite of 17beta-estradiol, on adipocyte growth has been investigated in mouse brown adipose tissue precursor cells developed in primary culture. 2ME inhibits brown adipocyte proliferation in a dose-response manner (IC50 = 1.7 x 10(-6) M for DNA synthesis), with much higher potency than its hormone precursor 17beta-estradiol, and cells acquire the typical differentiated morphology--more round with a higher content of triglycerides. 2ME causes similar effects in the immortal brown adipocyte tumor-derived hibernoma cell line HIB 1B and the immortal 3T3-F442A white adipocyte line. These findings suggest a possible role for 2ME in adipocyte proliferation, and probably in the differentiation process, entering the cells in the adipogenic program.
17β-雌二醇的天然哺乳动物代谢产物2-甲氧基雌二醇（2ME）对原代培养的小鼠棕色脂肪组织前体细胞中脂肪细胞生长的影响已得到研究。2ME以剂量反应方式抑制棕色脂肪细胞增殖（DNA合成的IC50 = 1.7×10⁻⁶ M），其效力远高于其激素前体17β-雌二醇，并且细胞获得典型的分化形态——更圆且甘油三酯含量更高。2ME在永生化的棕色脂肪细胞肿瘤来源的冬眠瘤细胞系HIB 1B和永生化的3T3-F442A白色脂肪细胞系中产生类似作用。这些发现表明2ME在脂肪细胞增殖中可能起作用，并且可能在分化过程中起作用，参与脂肪生成程序中的细胞活动。
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