Aisen P S, Luddy A, Durner M, Reinhard J F, Pasinetti G M
Department of Psychiatry, Mount Sinai Medical Center, New York, NY 10029, USA.
J Neurol Sci. 1998 Nov 26;161(1):66-9. doi: 10.1016/s0022-510x(98)00268-8.
The importance of inflammatory/immune mechanisms in Alzheimer's disease is supported by evidence that the human leukocyte antigen (HLA)-DR genotype influences risk of the disease, with a protective effect associated with the HLA-DR4 allele. We investigated the influence of the HLA-DR4 allele on glial activity, assessed by quantification of glial fibrillary acidic protein (GFAP), in hippocampal tissue from subjects with Alzheimer's disease. The mean GFAP level was significantly higher in Alzheimer's disease hippocampal specimens lacking the HLA-DR4 allele compared to specimens with similar neuropathological findings that were HLA-DR4 positive. Apolipoprotein E genotype had no influence on GFAP levels. These results indicate that HLA-DR4 may exert a protective influence on Alzheimer's disease via modulation of glial activity.
人类白细胞抗原（HLA）-DR基因型影响阿尔茨海默病风险，且HLA-DR4等位基因具有保护作用，这一证据支持了炎症/免疫机制在阿尔茨海默病中的重要性。我们研究了HLA-DR4等位基因对阿尔茨海默病患者海马组织中神经胶质活性的影响，通过对胶质纤维酸性蛋白（GFAP）进行定量评估。与具有相似神经病理学发现且HLA-DR4呈阳性的标本相比，缺乏HLA-DR4等位基因的阿尔茨海默病海马标本中GFAP平均水平显著更高。载脂蛋白E基因型对GFAP水平没有影响。这些结果表明，HLA-DR4可能通过调节神经胶质活性对阿尔茨海默病发挥保护作用。
